Publications by Biophoenix' Principals

Nonisotopic Immunoassay Markets in Europe: Reagents, Instrumentation, and Systems
Publisher:Frost & Sullivan Inc
Year of publication:1990
Type of publication:Market report
Publisher's reference (if any):N/A
Author(s):Sreten Bogdanovic
Approximate page count:250
Price when published:$3,400
Remarks:
  1. Page numbers, where given, refer to the draft manuscript (which may differ from the published version).
  2. The copyright in this report is owned by the publisher, to whom any requests for copies should be addressed.
                NON-ISOTOPIC IMMUNOASSAY MARKETS IN EUROPE:
                   REAGENTS, INSTRUMENTATION AND SYSTEMS
                                       
                                       
                             FROST & SULLIVAN INC.
                                       
                                       
                                C O N T E N T S

                                                               Page


EXECUTIVE SUMMARY                                              ES.1

CHAPTER 1:  INTRODUCTION, SCOPE AND METHODOLOGY                 1.1

1.1     Introduction                                            1.1

1.2     Objectives and Scope of this Report                     1.4

1.3     Definitions - Product Groups, Application Groups
        and End-users Covered in the Report                     1.6

1.4     Outline of the Report                                   1.8

1.5     Information Sources and Methodology                     1.11

1.6     Currency Exchange Rates                                 1.13


CHAPTER 2:  IMMUNOASSAY TECHNOLOGY AND PRODUCTS                 2.1

2.1     Introduction                                            2.1

2.2     Technological Basis of Immunoassays                     2.2

        2.2.1   Introduction                                    2.2
        2.2.2   Separation Methods and Formats                  2.7
        2.2.3   Labels, End Signals and Readers                 2.8
        2.2.4   Types of Instrumentation                        2.15

                2.2.4.1 Introduction                            2.15
                2.2.4.2 Nephelometers                           2.15
                2.2.4.3 Spectrophotometers                      2.16
                2.2.4.4 Fluorimeters                            2.16
                2.2.4.5 Luminometers                            2.17

        2.2.5   The Automation Challenge                        2.17
        2.2.6   Immunoassay Systems                             2.22

2.3     Non-isotopic Immunoassay Products                       2.26

        2.3.1   Nephelometric Immunoassay Products              2.26

                2.3.1.1 Reagents                                2.26
                2.3.1.2 Instruments                             2.28
                2.3.1.3 Semi- and Fully Automated Systems       2.29

        2.3.2   Colourimetric Immunoassay Products              2.33

                2.3.2.1 Reagents                                2.33
                2.3.2.2 Instrumentation                         2.37

        2.3.3   Fluorimetric Immunoassay Products               2.40

                2.3.3.1 Introduction                            2.40
                2.3.3.2 Reagents                                2.43
                2.3.3.3 Instrumentation                         2.44

        2.3.4   Chemiluminometric Assays                        2.47

                2.3.4.1 Introduction                            2.47
                2.3.4.2 Reagents                                2.47
                2.3.4.3 Instruments                             2.49

        2.3.5   Component Systems                               2.51
        2.3.6   Proprietary Modular Systems                     2.54
        2.3.7   Fully Automated Immunoassay Systems             2.54
        2.3.8   Automated Systems for Homogeneous
                Immunoassay                                     2.76

2.4     Definitions of the Product Groups Used for the
        Quantitative Market Analyses                            2.81


CHAPTER 3:      APPLICATIONS AND END-USERS OF NON-ISOTOPIC
                IMMUNOASSAY PRODUCTS, AND MARKET
                SEGMENTATION                                    3.1

3.1     Applications                                            3.1

        3.1.1   Thyroid                                         3.1
        3.1.2   Reproductive Endocrinology                      3.2

                3.1.2.1 LHRH, LH, FSH                           3.2
                3.1.2.2 Human Prolactin                         3.4

        3.1.3   Other Endocrinology                             3.4

                3.1.3.1 ACTH and Cortisol                       3.4
                3.1.3.2 Renin - Angiotensin - Aldosterone       3.5
                3.1.3.3 Growth Hormone                          3.5
                3.1.3.4 Parathormone                            3.5

        3.1.4   Haematology                                     3.6
        3.1.5   Allergy                                         3.6
        3.1.6   Cancer                                          3.7
        3.1.7   Therapeutic Drug Monitoring/Drugs of Abuse      3.8
        3.1.8   Plasma Proteins                                 3.9
        3.1.9   Serology                                        3.10
        3.1.10  Hepatitis                                       3.11

                3.1.10.1        Hepatitis A                     3.11
                3.1.10.2        Hepatitis B                     3.11
                3.1.10.3        Hepatitis C (Non-A Non-B)       3.12
                3.1.10.4        Delta Hepatitis                 3.12
                3.1.10.5        Hepatitis E                     3.12

        3.1.11  HIV                                             3.13

3.2     End-users of Non-isotopic Immunoassay Products
        & Market Segmentation                                   3.14

        3.2.1   Hospital Laboratories                           3.14
        3.2.2   Private and Commercial Laboratories             3.15
        3.2.3   Blood Transfusion Centres                       3.16
        3.2.4   Public Health/Hygiene Institutes                3.17
        3.2.5   Group Practice Laboratories                     3.17
        3.2.6   Market Segmentation                             3.18

                3.2.6.1 Factors to be Considered                3.18
                3.2.6.2 Market Segmentation for the Markets
                        under Review                            3.21


CHAPTER 4:  EUROPEAN ANALYSIS AND FORECASTS                     4.1

4.1  Political and Socio-economic Structure                     4.1

        4.1.1   European Overview - The EC, EFTA and
                Comecon Trading Blocks                          4.1
        4.1.2   Population and Demographic Trends               4.3
        4.1.3   GDP and Healthcare Expenditure                  4.5

4.2     Healthcare Systems in Europe                            4.8

4.3     Regulatory Controls                                     4.11

        4.3.1   France                                          4.11
        4.3.2   Germany                                         4.13
        4.3.3   Italy                                           4.14
        4.3.4   UK                                              4.14
        4.3.5   Other Countries in Europe                       4.15

4.4     EEC Market Harmonisation in 1992                        4.16

        4.4.1   General                                         4.16
        4.4.2   Patents and Trademarks                          4.19
        4.4.3   Diagnostics Industry Implications               4.20

                4.4.3.1 General                                 4.20
                4.4.3.2 Pricing Policy                          4.20
                4.4.3.3 Speed of New Product Adoption           4.20
                4.4.3.4 Effects of 1992 on End-customers        4.21
                4.4.3.5 Competitive Position                    4.21

4.5     Immunoassay Reagents, Instruments and Systems
        Markets in Europe                                       4.23

        4.5.1   European Overview                               4.23
        4.5.2   European Market Size and Product Group
                Breakdown                                       4.26
        4.5.3   European Market: Trends in Non-isotopic
                Reagents and Instrumentation Product Groups
                and Market Projections 1989-1995                4.32
        4.5.4   National Markets Overview and Projections       4.40
        4.5.5   Applications Group Overview and Projections     4.47
        4.5.6   End-user Overview                               4.55
        4.5.7   The Competitive Situation in the European
                Market                                          4.61


CHAPTER 5:  IMMUNOASSAY REAGENTS,INSTRUMENTS AND SYSTEMS:
                   EUROPEAN NATIONAL MARKETS ANALYSIS           5.1

5.1     France  5.1

        5.1.1   Introduction                                    5.1
        5.1.2   The French Healthcare System                    5.1
        5.1.3   The French Hospital System                      5.5

                5.1.3.1 Public Hospitals                        5.5
                5.1.3.2 Private Hospitals                       5.9

        5.1.4   Hospital Laboratory Sites                       5.9
        5.1.5   Private Laboratories in France                  5.10
        5.1.6   Immunoassays in French Laboratories             5.14
        5.1.7   French Non-isotopic Immunoassay Reagents,
                Instruments and Systems Markets                 5.18

5.2     Germany                                                 5.34

        5.2.1   Introduction                                    5.34
        5.2.2   Healthcare in the Western L„nder                5.35

                5.2.2.1 Introduction                            5.35
                5.2.2.2 The Hospital System                     5.38
                5.2.2.3 Ambulatory Care                         5.40

                5.2.2.4 Hospital Laboratories in the Western
                        L„nder                                  5.43
                5.2.2.5 Private Laboratories in the Western
                        L„nder                                  5.43
                5.2.2.6 Immunoassay in the Western L„nder       5.46

        5.2.3   The Eastern Region                              5.47

                5.2.3.1 Introduction                            5.47
                5.2.3.2 Hospitals                               5.48
                5.2.3.3 Ambulatory Care                         5.50
                5.2.3.4 Laboratories in the Eastern L„nder      5.50

        5.2.4   Unification of German Healthcare                5.52
        5.2.5   German Non-isotopic Immunoassay Reagents,
                Instruments and Systems Markets                 5.53

5.3     Italy                                                   5.69

        5.3.1   Introduction                                    5.69
        5.3.2   The Italian Healthcare System                   5.69
        5.3.3   The Italian Hospital System                     5.74

                5.3.3.1 Italian Public Hospitals                5.74
                5.3.3.2 Italian Private Hospitals               5.75
                5.3.3.3 Hospital Size Distribution              5.78

        5.3.4   Hospital Laboratory Sites                       5.78
        5.3.5   Poliambulatorios and USL Laboratories           5.80
        5.3.6   Private Laboratories in Italy                   5.80
        5.3.7   The Italian Non-isotopic Immunoassay
                Reagents, Instruments and Systems Market        5.81
        5.3.8   Competition in the Italian Market               5.96

5.4     United Kingdom                                          5.100

        5.4.1   Introduction                                    5.100
        5.4.2   The UK Hospital System                          5.104

                5.4.2.1 UK Public Hospitals                     5.104
                5.4.2.2 UK Private Hospitals                    5.105
                5.4.2.3 Ambulatory Medicine in the UK           5.109

        5.4.3   The UK Laboratory System                        5.110
        5.4.4   Immunoassay in UK Laboratories                  5.112
        5.4.5   The Non-isotopic Reagents, Instrumentation
                and Systems Markets in the UK                   5.114

5.5     Spain                                                   5.129

        5.5.1   Introduction                                    5.129
        5.5.2   The Spanish Healthcare System                   5.131
        5.5.3   Spanish Hospitals                               5.132
        5.5.4   Ambulatory Care in Spain                        5.139
         5.5.5   The Spanish Clinical Laboratory System          5.140
        5.5.6   The Non-isotopic Immunoassay Reagents,
                Instrumentation and Systems Market in Spain     5.142

5.6     Other National Markets in the Rest of Europe            5.158

        5.6.1   Belgium                                         5.158

                5.6.1.1 Introduction                            5.158
                5.6.1.2 The Belgian Healthcare System           5.158
                5.6.1.3 Hospitals in Belgium                    5.160
                5.6.1.4 Ambulatory Care in Belgium              5.163
                5.6.1.5 The Belgian Laboratory System           5.163

        5.6.2   The Netherlands                                 5.166

                5.6.2.1 Introduction                            5.166
                5.6.2.2 Healthcare in the Netherlands           5.167
                5.6.2.3 The Hospital System in the Netherlands  5.170
                5.6.2.4 Ambulatory Care in the Netherlands      5.170
                5.6.2.5 The Laboratory System in the
                        Netherlands                             5.172

        5.6.3.  Scandinavia                                     5.172

                5.6.3.1 Introduction                            5.172
                5.6.3.2 Denmark                                 5.174
                5.6.3.3 Sweden                                  5.177
                5.6.3.4 Norway                                  5.178
                5.6.3.5 Finland                                 5.178

        5.6.4   Austria and Switzerland                         5.179

                5.6.4.1 Introduction                            5.179
                5.6.4.2 Austria                                 5.179
                5.6.4.3 Switzerland                             5.182

        5.6.5   Ireland, Greece and Portugal                    5.184
        5.6.6   Non-isotopic Immunoassay reagents,
                Instruments and Systems Market in the
                Rest of Europe                                  5.187


CHAPTER 6:  SUPPLIER PROFILES                                   6.1

6.1     Abbott Laboratories, Inc                                6.1
6.2     Amerlite Diagnostics                                    6.4
6.3     Baxter International                                    6.6
6.4     Beckman Instruments Inc                                 6.9
6.5     Behringwerke                                            6.11
6.6     Biomerieux                                              6.12
6.7     Boehringer Mannheim                                     6.14
6.8     Diagnostics Pasteur                                     6.16
6.9     Organon Teknika                                         6.18
6.10    Pharmacia                                               6.19
6.11    Roche                                                   6.22
6.12    Ares-Serono Group                                       6.24
6.13    Sorin Biomedica                                         6.26
6.14    Syva Corporation                                        6.27
6.15    Wellcome Diagnostics                                    6.28


CHAPTER 7:  TRENDS, OPPORTUNITIES AND STRATEGIES                7.1


APPENDIX I:  LIST OF SUPPLIERS' ADDRESSES                       A.1



                        FIGURES AND TABLES

                                                                Page

EXECUTIVE SUMMARY

Fig ES1         Non-isotopic Immunoassay Reagents.
                European Market, by Country (1989)              ES.3

Table ES2       Europe: Installed Base of NIA instruments/
                Systems (mid 1990) by National Market           ES.5

Fig ES3         Non-isotopic Immunoassay Reagents.
                European Market, by Application (1989)          ES.6

Fig ES4         Non-isotopic Immunoassay Reagents Market.
                European Market, by End-user Segment for
                the Top Five Countries in 1989                  ES.8

Fig ES5         Non-isotopic Immunoassay Reagents Market
                in Europe.  Breakdown by Instrument/
                Systems Type (1989)                             ES.9

Fig ES6         Non-isotopic Immunoassay Reagents Market.
                European Market, by Country, 1989 and 1995.     ES.11

Table ES7       Europe: NIA Reagents Market Projections by
                National Market (1989-95)                       ES.12

Table ES8       Europe: NIA Reagents Market Projections by
                Application Group (1989-1995)                   ES.13

Table ES9       Europe: NIA Instrumentation/Systems
                Projections. Placements by Type (1989-1995)     ES.16

Table ES10      Europe: NIA Instrumentation/Systems
                Projections.  Installed Base (1989-1995)        ES.17

Fig ES11        Fully Automated Systems.  Availability of
                Key Analytes 1990-95                            ES.18

Table ES12      Europe: NIA Reagents Market Projections by
                Type of Instrumentation Systems 1989-1995)      ES.19

Fig ES13        Non-isotopic Immunoassay Reagents Market
                in Europe.  Projections by Instrument/
                System Type                                     ES.20

Table ES14      Europe: NIA Reagents Market (1989).  Share
                by Supplier                                     ES.21


CHAPTER 1: INTRODUCTION, SCOPE AND METHODOLOGY

Table 1.1       Currency Exchange Rates                         1.14


CHAPTER 2:  IMMUNOASSAY TECHNOLOGY AND PRODUCTS

Table 2.1       Common Combinations of Labels and Instruments
                used in Commercial Non-isotopic Immunoassays    2.14

Table 2.2       Nephelometric Instruments and Systems           2.30

Table 2.3       Test Menus of Beckman and Behring Nephelo-
                metric Immunoassay Systems                      2.32

Table 2.4       Colourimetric Immunoassay Reagents              2.36

Table 2.5       Colourimetric Immunoassay Instrumentation       2.41

Table 2.6       Fluorimetric Immunoassays                       2.46

Table 2.7       Chemiluminometric Immunoassays                  2.50

Table 2.8       Fully Automated Immunoassay Systems:
                Late 1990                                       2.56

Table 2.9       Fully Automated Immunoassay Systems             2.58

Fig 2.10        Abbott: IMX                                     2.59

Fig 2.11        Baxter-Dade: Stratus II                         2.60

Fig 2.12        Becton Dickinson: Affinity                      2.61

Fig 2.13        Biomerieux: Vidas                               2.62

Fig 2.14        Biotrol: S7000                                  2.63

Fig 2.15        Boehringer-Mannheim: ES600                      2.64

Fig 2.16        Boehringer-Mannheim: ES300                      2.65

Fig 2.17        Ciba Corning: ACS-180                           2.66

Fig 2.18        Cis Bio International: Cis Pack 4200            2.67

Fig 2.19        Mitsui: Quatrus                                 2.68

Fig 2.20        Olympus: PK310                                  2.69

Fig 2.21        Polaroid-Behring: Opus                          2.70

Fig 2.22        Serono: SRI                                     2.71

Fig 2.23        Technicon: Immuno-I                             2.72

Fig 2.24        Tosoh (Eurogenetics): AIA-600                   2.73

Fig 2.25        Tosoh (Eurogenetics): AIA-1200                  2.74

Table 2.26      44 Key Non-isotopic Immunoassay Analytes        2.77

Fig 2.27        Fully Automated systems.  Availability of
                Key Analytes 1990-95                            2.78


CHAPTER 3:      APPLICATIONS AND END-USERS OF NON-ISOTOPIC
                IMMUNOASSAY PRODUCTS, AND MARKET SEGMENTATION

Fig 3.1         Strategies for Thyroid Testing                  3.3

Table 3.2       Market Segmentation Factors for End-users
                in the European Market                          3.23


CHAPTER 4:      EUROPEAN MARKET ANALYSIS AND FORECASTS

Table 4.1       Population, Economic & Healthcare Indicators
                - Comparative Data for European Countries
                Covered in this Report                          4.4

Table 4.2       Population and GDP Statistics for Eastern
                European Countries (1988)                       4.6

Table 4.3       Summary of European Immunodiagnostic
                Regulations                                     4.12

Table 4.4       Europe: Numbers of NIA Instruments/
                Systems in Service by Type (mid 1990) and
                1989 Placements by Type                         4.28

Table 4.5       Europe: The Market for NIA Reagents by Type
                of Instrumentation/System (1989)                4.30

Table 4.6       Europe: Non-isotopic Immunoassay Reagents
                Market Projections 1989-1995                    4.33

Table 4.7       Europe: NIA Instrumentation/Systems
                Projections.  Installed Base (1989-1995)        4.35

Table 4.8       Europe: NIA Instrumentation/Systems
                Projections. Placements by Type (1989-1995)     4.36

Table 4.9       Europe: NIA Reagents Market Projections by
                Type of Instrumentation/Systems (1989-1995)     4.37

Table 4.10      Europe: The Market for NIA Reagents by Type
                of Instrumentation/System.  Comparison of
                the Market in 1995 with that of 1989            4.41

Table 4.11      Europe: The Market for NIA Reagents by
                National Market (1989)                          4.43

Table 4.12      Europe: Installed Base of NIA Instrumentation/
                Systems (mid 1990) by National Market           4.44

Table 4.13      Europe: The Market for NIA Reagents ($m) by
                Type of Instrumentation/System (1989) by
                National Market                                 4.45

Table 4.14      Main Contributors to Growth in the Non-
                isotopic Immunoassay Reagents Markets in
                Europe                                          4.48

Table 4.15      Europe: NIA Reagents Market Projections by
                National Market (1989-95)                       4.49

Table 4.16      Europe: The Market for NIA Reagents by
                Application Group (1989)                        4.50

Table 4.17      Europe: NIA Reagents Market Projections by
                Application Group (1989-1995)                   4.54

Table 4.18      Europe: The Market for NIA Reagents by
                End-user Segment (1989) for the Top 5
                National Markets                                4.56

Table 4.19      Europe: NIA Reagents Market (1989).  Share
                by Supplier                                     4.62

Table 4.20      Europe: Numbers of NIA Instruments/
                Systems in Service in Mid 1990, and Share
                by Manufacturer.                                4.63

CHAPTER 5:      NATIONAL MARKETS IN EUROPE

Table 5.1       Demographic and Economic Indicators -
                France                                          5.2

Table 5.2       Healthcare Indicators - France                  5.3

Table 5.3       French Public Hospitals: Distribution by
                Type and Bed Size Category (1989)               5.6

Table 5.4       Number of French Public Hospitals by Type
                and by Total Bed Capacity (1988)                5.6

Table 5.5       French Public Short Stay Hospitals:
                Distribution by Bed Size Capacity.
                Number and Percentage of Short Stay Beds        5.7

Table 5.6       Type and Size Distribution of French
                Private Hospitals (1988)                        5.7

Table 5.7       Clinical Laboratories in France                 5.11

Table 5.8       Private Laboratories in France:
                Distribution of Reimbursement Revenues          5.12

Table 5.9       Approval of Immunoassays for
                Reimbursement in France (1986-1990)             5.15

Table 5.10      France: The Market for NIA Reagents by
                Application Group                               5.19

Table 5.11      France: The Market for NIA Reagents by
                End-user Segment (1989)                         5.21

Table 5.12      France: Numbers of NIA Instruments/
                Systems in Service by Type (mid 1990)
                and 1989 Placements by Type                     5.22

Table 5.13      France: The Market for NIA Reagents by
                Type of Instrumentation/System (1989)           5.23

Table 5.14      France: NIA Reagents Market Projections by
                Application Group (1989-1995)                   5.25

Table 5.15      France: NIA Instrumentation/Systems
                Projections.  Numbers in Service by Type
                (1989-1995)                                     5.27

Table 5.16      France: NIA Instrumentation/Systems
                Projections.  Placements by Type (1989-1995)    5.28

Table 5.17      France: The Market for NIA Reagents by Type
                of Instrumentation/System.  Comparison of
                the Market in 1995 with that of 1989            5.29

Table 5.18      France: NIA Reagents Market Projections by
                Type of Instrumentation/System (1989-1995)      5.30

Table 5.19      France: NIA Reagents Market (1989).  Share
                by Supplier                                     5.32

Table 5.20      Demographic and Economic Indicators -
                Germany                                         5.36

Table 5.21      Healthcare Indicators - Germany                 5.37

Table 5.22      German Hospitals: Distribution by Type and
                Bed Size Category (1987).  All Hospitals        5.39

Table 5.23      German Hospitals: Distribution by Type and
                Bed Size Category (1987).  Acute Hospitals      5.41

Table 5.24      Numbers and Type of German Hospitals in the
                Western L„nder, and Total Bed Capacity (1987)   5.41

Table 5.25      Clinical Laboratories in Germany (Western
                L„nder)                                         5.44

Table 5.26      Numbers and Type of German Hospitals in the
                Eastern L„nder, and Total Bed Capacity (1988)   5.49

Table 5.27      Ambulatory Care Facilities in the Eastern
                Region of Germany                               5.51

Table 5.28      Germany: The Market for NIA Reagents by
                Application Group (1989)                        5.54

Table 5.29      Germany: The Market for NIA Reagents by
                End-user Segment (1989)                         5.56

Table 5.30      Germany: Numbers of NIA Instruments/Systems
                in Service by Type (mid 1990) and 1989
                Placements by Type                              5.57

Table 5.31      Germany: The Market for NIA Reagents by Type
                of Instrumentation/System (1989)                5.58

Table 5.32      Germany: NIA Reagents Market Projections by
                Application Group (1989-1995)                   5.60

Table 5.33      Germany: NIA Instrumentation/Systems
                Projections.  Numbers in Service by Type
                (1989-1995)                                     5.63

Table 5.34      Germany: NIA Instrumentation/Systems
                Projections.  Placements by Type (1989-1995)    5.64

Table 5.35      Germany: Market Projections by Type of
                Instrumentation/System (1989-1995)              5.65

Table 5.36      Germany The Market for NIA Reagents by Type
                of Instrumentation/System.  Comparison of
                the Market in 1995 with that of 1989            5.66

Table 5.37      Germany: NIA Reagents Market (1989).  Share
                by Supplier                                     5.68

Table 5.38      Demographic and Economic Indicators - Italy     5.70

Table 5.39      Healthcare Indicators: Italy                    5.72

Table 5.40      Number and Type of Italian Public Hospitals     5.76

Table 5.41      Number and Type of Italian Public Hospitals
                and Distribution of Bed Capacity                5.76

Table 5.42      Number, Type and Bed Capacity of Italian
                Private Hospitals                               5.77

Table 5.43      Italian General Hospitals: Distribution by
                Bed Size Category and Bed Capacity              5.79

Table 5.44      Clinical Laboratories in Italy                  5.82

Table 5.45      Italy: The Market for NIA Reagents by
                Application Group (1989)                        5.83

Table 5.46      Italy: The Market for NIA Reagents by
                End-User Segment (1989)                         5.86

Table 5.47      Italy: Numbers of NIA Instruments/Systems
                in Service by Type (mid 1990) and 1989
                Placements by Type                              5.87

Table 5.48      Italy: The Market for NIA Reagents by Type
                of Instrumentation/System (1989)                5.88

Table 5.49      Italy: NIA Reagents Market Projections by
                Application Group (1989-1995)                   5.90

Table 5.50      Italy: NIA Instrumentation/Systems
                Projections.  Numbers in Service (1989-1995)    5.92

Table 5.51      Italy: NIA Instrumentation/Systems
                Projections.  Placements by Type (1989-1995)    5.93

Table 5.52      Italy: Market Projections by Type of
                Instrumentation System (1989-1995)              5.94

Table 5.53      Italy: The Market for NIA Reagents by Type
                of Instrumentation/System.  Comparison of
                the Market in 1995 with that of 1989            5.95

Table 5.54      Italy: NIA Reagents Market (1989).  Share
                by Supplier                                     5.97

Table 5.55      Demographic & Economic Indicators for
                the UK                                          5.101

Table 5.56      Healthcare Indicators: UK                       5.102

Table 5.57      Public Hospitals in the UK: Total Numbers,
                Bed Capacity and Breakdown by Bed Size
                Category                                        5.106

Table 5.58      Public Hospitals in the UK - Unofficial
                Statistics.  Breakdown of Acute and General
                Hospitals by Bed Size Category for Hospitals
                with 100 or More Beds                           5.107

Table 5.59      Number, Type and Bed Capacity of Private
                Acute Hospitals in the UK                       5.108

Table 5.60      Clinical Laboratories in the UK                 5.113

Table 5.61      UK: The Market for NIA Reagents by
                Application Group (1989)                        5.116

Table 5.62      UK: The Market for NIA Reagents by
                End-User Segment (1989)                         5.117

Table 5.63      UK: Numbers of NIA Instruments/Systems in
                Service by Type (mid 1990) and 1989
                Placements by Type                              5.119

Table 5.64      UK: The Market for NIA Reagents by Type
                of Instrumentation/System (1989)                5.120

Table 5.65      UK: NIA Reagents Market Projections by
                Application Group (1989-1995)                   5.121

Table 5.66      UK: NIA Instrumentation/Systems
                Projections.  Numbers in Service by Type
                (1989-1995)                                     5.123

Table 5.67      UK: NIA Instrumentation/Systems
                Projections.  Placements by Type (1989-1995)    5.124

Table 5.68      UK: Market Projections by Type of
                Instrumentation System (1989-1995)              5.125

Table 5.69      UK: The Market for NIA Reagents by Type of
                Instrumentation/System.  Comparison of the
                Market in 1995 with that of 1989                5.126

Table 5.70      UK: NIA Reagents Market (1989).  Share by
                Supplier                                        5.127

Table 5.71      Demographic and Economic Indicators - Spain     5.130

Table 5.72      Healthcare Indicators: Spain                    5.133

Table 5.73      Number, Type and Bed Capacity of Spanish
                Hospitals (1987). Latest Official Statistics    5.134

Table 5.74      Spanish Hospitals (1987): Breakdown
                by Function and Bed Capacity.  Latest
                Official Statistics                             5.136

Table 5.75      Breakdown by Bed Size Category and Function
                for Spanish Hospitals (1987)                    5.137

Table 5.76      Breakdown by Bed Size Category and
                Administration of Spanish Hospitals (1987).
                Latest Official Statistics                      5.138

Table 5.77      Clinical Laboratories in Spain                  5.141

Table 5.78      Spain: The Market for NIA Reagents by
                Application Group (1989)                        5.143

Table 5.79      Spain: The Market for NIA Reagents by
                End-User Segment (1989)                         5.144

Table 5.80      Spain: Numbers of NIA Instruments/Systems
                in Service by Type (mid 1990) and 1989
                Placements by Type                              5.146

Table 5.81      Spain: The Market for NIA Reagents by Type
                of Instrumentation/System (1989)                5.147

Table 5.82      Spain: NIA Reagents Market Projections by
                Application Group (1989-1995)                   5.149

Table 5.83      Spain: The Market for NIA Reagents by Type
                of Instrumentation/System.  Comparison of
                the Market in 1995 with that of 1989            5.151

Table 5.84      Spain: NIA Instrumentation/Systems
                Projections.  Numbers in Service by Type
                (1989-1995)                                     5.152

Table 5.85      Spain: NIA Instrumentation/Systems
                Projections. Placements by Type (1989-1995)     5.153

Table 5.86      Spain: Market Projections by Type of
                Instrumentation System (1989-1995)              5.154

Table 5.87      Spain: NIA Reagents Market (1989).  Share
                by Supplier                                     5.156

Table 5.88      Demographic and Economic Indicators:
                Belgium                                         5.159

Table 5.89      Healthcare Indicators: Belgium                  5.161

Table 5.90      Number and Type of Belgian Hospitals            5.162

Table 5.91      Belgian Hospitals: Breakdown by Type and
                Bed Size Category                               5.162

Table 5.92      Clinical Laboratories in Belgium - 1987         5.165

Table 5.93      Demographic and Economic Indicators: The
                Netherlands                                     5.168

Table 5.94      Healthcare Indicators: The Netherlands          5.169

Table 5.95      Hospitals in The Netherlands: Breakdown by
                Function (1988)                                 5.171

Table 5.96      General Hospitals in The Netherlands:
                Breakdown by Bed Size                           5.171

Table 5.97      Clinical Laboratories in The Netherlands        5.173

Table 5.98      Population and Demographic Indicators for
                Scandinavia                                     5.175

Table 5.99      Healthcare Indicators for Scandinavia (1988)    5.176

Table 5.100     Population and Demographic Indicators:
                Austria & Switzerland                           5.180

Table 5.101     Healthcare Indicators: Austria & Switzerland
                (1987)                                          5.180

Table 5.102     Demographic, Economic and Healthcare
                Indicators: Ireland, Greece & Portugal          5.185

Table 5.103     Non-isotopic Immunoassay Reagents Markets in
                the Rest of Europe.  Breakdown by National
                Markets.                                        5.188

Table 5.104     Other Countries: NIA Reagents Market Project
                -ions by Application Group (1989-1995)          5.190

Table 5.105     Other Countries: NIA Instrumentation/Systems
                Projections.  Numbers in Service by Type
                (1989-1995)                                     5.192

Table 5.106     Other Countries: NIA Instrumentation/Systems
                Projections. Placements by Type (1989-1995)     5.194

Table 5.107     Rest of Europe: The Market for NIA Reagents
                by Type of Instrumentation/System.
                Comparison of the Market in 1995 with that
                of 1989                                         5.195

Table 5.108     Other Countries: Market Projections by Type
                of Instrumentation System (1989-1995)           5.196




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