OLIGONUCLEOTIDE THERAPEUTICS
A FINANCIAL TIMES BIOFRONTIERS REPORT
(1999)
TABLE OF CONTENTS
EXECUTIVE SUMMARY
CHAPTER 1 MARKET AND TECHNOLOGY OVERVIEW
INTRODUCTION AND SCOPE
A PRIMER ON DNA, RNA, AND THE MECHANISM OF ANTISENSE ACTION
THERAPEUTIC APPLICATIONS OF ANTISENSE
REVIEW OF OLIGONUCLEOTIDE CHEMISTRIES
First generation oligonucleotides
Second generation oligonucleotides
Third generation oligonucleotides
NOVEL TYPES OF OLIGONUCLEOTIDES
Gene-targeting oligonucleotides
Protein-targeting oligonucleotides
Ribozymes and other catalytic oligonucleotides
DELIVERY OF OLIGONUCLEOTIDES
Enhancement of stability and cellular uptake
Targeted delivery
Non-invasive delivery
ANTISENSE OLIGONUCLEOTIDES UNDER COMMERCIAL INVESTIGATION
Highlights from clinical trials
Three generations of antisense products
Various antisense oligonucleotides
OTHER OLIGONUCLEOTIDES UNDER COMMERCIAL INVESTIGATION
Oligonucleotides with antiviral properties
Oligonucleotides with specific properties
Protein-binding oligonucleotides
TABLE 1.1 OLIGONUCLEOTIDE CHEMISTRIES
TABLE 1.2 NOVEL TYPES OF OLIGONUCLEOTIDES
TABLE 1.3 OLIGONUCLEOTIDE DELIVERY SYSTEMS
TABLE 1.4 THREE GENERATIONS OF ANTISENSE OLIGONUCLEOTIDES
TABLE 1.5 ANTISENSE OLIGONUCLEOTIDES (VARIOUS)
TABLE 1.6 OLIGONUCLEOTIDES NOT BASED ON ANTISENSE
CHAPTER 2 COMPANY PROFILES
LIST OF COMPANIES PROFILED
AMGEN INC
ANGIOGENE INC
ANTISOMA PLC
ARONEX PHARMACEUTICALS INC
ATLANTIC PHARMACEUTICALS INC
AVI BIOPHARMA INC
BAXTER INTERNATIONAL
BIORESEARCH IRELAND
BIOVECTOR THERAPEUTICS SA
BOEHRINGER INGELHEIM GMBH
BORON BIOLOGICALS INC
BRISTOL-MYERS SQUIBB CO
CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
CHIRON CORP
CHUGAI PHARMACEUTICAL CO. LTD
CRINOS INDUSTRIA FARMACOBIOLOGICA SPA
CRYOGENIC SOLUTIONS INC
CV THERAPEUTICS INC
DANBIOSYST UK LTD
DEPOTECH CORP
EPOCH PHARMACEUTICALS INC
GENESENSE TECHNOLOGIES INC
GENSET
GENTA INCORPORATED
GENZYME CORPORATION
GERON CORP
GILEAD SCIENCES INC
GLAXO WELLCOME PLC
HESED BIOMED INC
HOECHST AG
HUMAN GENOME SCIENCES INC
HYBRIDON INC
ICN PHARMACEUTICALS INC
IMMUNE RESPONSE CORP
INCYTE PHARMACEUTICALS INC
INEX PHARMACEUTICALS CORPORATION
INKINE PHARMACEUTICAL CO INC
INNOVIR LABORATORIES INC
INTERCARDIA INC
IOMED INC
ISIS PHARMACEUTICALS INC
KIMERAGEN INC
LYNX THERAPEUTICS INC
MEDTRONIC
METHYL-GENE INC
NEOPHARM INC
NEXSTAR PHARMACEUTICALS INC
NOVARTIS AG
NOVOPHARM BIOTECH INC
OLIGO THERAPEUTICS INC
ONCOR INC
PANTHECO A/S
RIBOZYME PHARMACEUTICALS INC
SANKYO COMPANY LTD
SEQUUS PHARMACEUTICALS INC
SRC VB VECTOR
SUPRATEK PHARMA INC
SYNSORB BIOTECH INC
TARGETED GENETICS CORP
THERATECHNOLOGIES INC
VICAL INC
VIMRx PHARMACEUTICALS INC
ZYNAXIS INC
CHAPTER 3 FINANCIAL AND MARKET ANALYSES
Markets for oligonucleotide therapeutics
Table 3.1 Important clinical indications for oligonucleotide
therapy
Table 3.2 World Pharmaceutical Market by Region in 1998
Table 3.3 Sizes of Oligonucleotide-related Pharma Markets
in 1998
Table 3.4 Oligonucleotides In Clinical Trials
Table 3.5 Oligonucleotide therapeutics market in 1999 and
2005
Table 3.6 Top 35 Companies Ranked by Total Revenues
Table 3.7 Top 35 Companies Ranked by Net Income/Loss
Table 3.8 Top 35 Companies Ranked by Total Assets
Table 3.9 Top 35 Companies Ranked by R&D Expenditure
Table 3.10 Exchange Rates Used in This Alert
CHAPTER 4 TRENDS AND OPPORTUNITIES
Antisense therapeutics - an area of opportunity
Third generation oligonucleotides - cheaper yet better
New perspectives in delivery of oligonucleotides
Prospects for large-scale oligonucleotide synthesis
Applications of antisense to drug and gene target validation
Oligonucleotide strategies not based on antisense
Patent analysis
Table 4.1 Oligonucleotide therapeutic patents, by subject
Table 4.2 US Patents Concerning Oligonucleotides Targeted at
Specific Genes
Table 4.3 US Patents Concerning Modified Oligonucleotides
Table 4.4 US Patents Concerning Oligonucleotide Delivery
Methods
Table 4.5 US Oligonucleotide Patents Concerning General
Therapeutic Methods
Table 4.6 Patenting activity by Organisation
Table 4.7 Patent Citations by Organisation
Table 4.8 Top 10 Patent Citations in Oligonucleotide
Therapeutics
TERMS AND ABBREVIATIONS
|
